Endocrine Abstracts

A 45-year-old lady presented to her GP with sweating, poor memory, and decreased, concentration. Investigations revealed elevated oestradiol at 2204 pmol/l, LH at 28.1 IU/l, and FSH at 15.0 IU/l. This raised the possibility of a Gonadotrophinoma. A preclinic pituitary MRI showed a subtle rounded nodule of tissue within the right side of the anterior pituitary. In clinic, she revealed that she was consuming aloe vera juice for several years to improve her skin and general well-...

A 60-year-old South African male, presented as an emergency with a 4 week history of lethargy, polyuria, increased thirst, constipation and weight loss. Blood tests revealed hypercalcemia with CCa-4.72 mmol/l, PTH-159.3pmol/l and 25 OH Vitamin D 22mmol/l. Intensive iv hydration was followed by IV Pamidronate 60 mg stat. Calcitonin (4 units/Kg tds) was started 48 hours later which resulted in a fall in the calcium to 2.66 by day 5. Cinacalcet 30 mg od was then introduced such t...

Case history: A 67-year-old lady was referred to endocrinology with an 8-year history of mild hyperparathyroidism with Parathyroid hormone of 7.4 -15.3 pmol/l (Normal -1.95-8.49). Her corrected calcium ranged from 2.46-2.66 mmol/l (Normal 2.2 -2.62), phosphate 0.63 -1.0 mmol/l (normal 0.8-1.5), normal renal function and normal vitamin D. Her urine calcium to creatinine ratio was 0.7 mmol/mmol (Normal 0-0.4).Investigations and treatment: She had myalgia d...

Case History: A 61-year-old Caucasian female from Ukraine presented with severe hypercalcaemia following routine blood tests performed by the GP. She reported symptoms of back pain and joint pains. She had renal stones 10 years prior. No history of thiazide or lithium use. No red flags; no change in appetite or weight loss. There was no familial history of Multiple Endocrine Neoplasia (MEN). Examination of her neck, cardiorespiratory, abdomen and breasts were normal. <p cl...